The production of Section.80 was mainly handled by TDE in-house producers from production group Digi+Phonics, as well as THC, Tommy Black, Wyldfyer, Terrace Martin and J. Cole. A concept album, it features lyrical themes delivered by Lamar such as the 1980s crack epidemic, racism and the medication tolerance of Generation Y. The album features guest appearances from GLC, Colin Munroe, Ashtrobot, BJ the Chicago Kid, Schoolboy Q, Ab-Soul and vocals from late singer-songwriter Alori Joh.
Section.80 received generally positive reviews from critics upon its release. The album debuted at number 113 on the US Billboard 200 and as of February 2014, it has sold 130,000 copies domestically. In April 2017, it was certified gold by the Recording Industry Association of America (RIAA).