The song reached number four on the US Billboard Hot 100 and reached the top 10 in nine other countries, including Ireland, Italy, and New Zealand, peaking within the top five in these regions. In the US, the song topped two Billboard listings: the Adult Top 40 and the Mainstream Top 40. "I'm with You" received radio and television airplay in Australia, but it was not officially released there. The track was nominated for several awards following its release, winning two ASCAP Awards, a BMI Pop Music Award, and a SOCAN Award. It was the second Lavigne song to be nominated for a Grammy in the categories Song of the Year and Best Female Pop Vocal Performance at the 46th Annual Grammy Awards.